1. Oleacein protects red blood cells (RBCs) from oxidative injury

In this work, Pavla-Martins studied the capacity of oleacein to protect red blood cells (RBCs) from oxidative injury. Oleacein was shown to significantly protect RBCs from oxidative damage in a dose-dependent manner. Even at low dosages exhibited a remarkable protective role for RBCs.​

https://www.ncbi.nlm.nih.gov/pubmed/19340892

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2. Oleacein: a potential Antiatherosclerotic Drug

Oleacein may play a special role in decreasing the progression of atherosclerosis, the most important cause of stroke or heart attack. Some bioactivities of oleacein have been already documented, further studies are needed about the usefulness of this compound in antiatherosclerotic therapy.

​ https://www.ncbi.nlm.nih.gov/pubmed/25312731

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3. The anti-inflammatory effect of oleacein and mechanisms of action

Filipek examined the ability of oleacein to increase the production of specific anti-inflammatory proteins. In particular, oleacein is either associated with specific blood components and induces the production of some anti-inflammatory proteins or inflammatory-related protein. Thus it seems that oleacein may play an important role in the prevention of inflammatory disease related to atherosclerosis.​https://www.ncbi.nlm.nih.gov/pubmed/26655408

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4. Oleacein protects cells from aging

Oleacein was examined if is able to protect cells from aging and hence from their death. Endothelial progenitor cells exposed to oleacein showed a significant increase of proliferation in a dose-dependent manner.​

https://www.ncbi.nlm.nih.gov/pubmed/23809250

 

5. Oleacein and its anti-inflammatory effect

Oleacein is one of the most potent inhibitors of 5-lipoxygenase, an enzyme associated with early stages of inflammation. Its action is more potent in comparison with oleocanthal and oleuropein. Thereby it is necessary to develop an anti-inflammatory drug based on oleacein.​

https://www.ncbi.nlm.nih.gov/pubmed/24568174

 

6. Oleacein reduces the ischemic stroke risk

Oleacein has an effect against the destabilization of carotid plaques, by affecting the production of specific proteins associated with atherosclerosis. Ex vivo experiments showed that oleacein has the potential to attenuate the destabilization of carotid plaques and may be useful in reducing the risk of ischemic stroke.

https://www.ncbi.nlm.nih.gov/pubmed/28732809

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7. Oleacein attenuates the pathogenesis of experimental autoimmune encephalomyelitis through both antioxidant and anti-inflammatory effects.

Oxidative stress and proinflammatory cytokines are factors affecting multiple sclerosis (MS) disease progression. Oleacein (OLE), an olive secoiridoid, possesses powerful antioxidant and anti-inflammatory activities, which suggests its potential application to treat neuroinflammatory disorders. 

https://pubmed.ncbi.nlm.nih.gov/33233421/

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