1. Low dosages of oleocanthal prove to be protective against Alzheimer's disease

 This study of Pitt et al indicates that oleocanthal is a substance capable of altering the assembly state of soluble oligomers of amyloid-β1-42 peptide (ADDL), which peptide is a neurotoxin that causes Alzheimer’s disease (AD). The results show that Oleocanthal protects the neurons from the negative effects of Alzheimer's disease even at low doses and as a result in the future it could be used in a potential thera​py.

https://www.ncbi.nlm.nih.gov/pubmed/19631677

 

2. Olive oil rich in oleocanthal effects the cardiovascular system’s           function

Olive oil oleocanthal levels, can significantly affect the cardiovascular benefits from its consumption. In this study, participants consumed 40ml of extra virgin olive oil (EVOO), with a known polyphenols concentration, so that they can evaluate the effects on blood platelets function, blood ingredients that are related to blood coagulation. The results were compared with ibuprofen action; a powerful antioxidant factor. This study showed that EVOO samples rich in oleocanthal and oleacein caused a significant decrease in platelet aggregation levels (more than 25% reduction), that is the main cause for blood clotting, indicating that oleocanthal intake holds the bigger part. Finally, seems that the effects of EVOO polyphenols is independent from their antioxidant action and turns out that the chemical profile of olive oil effects directly the cardiovascular system’s function.​

https://www.ncbi.nlm.nih.gov/pubmed/29904393

 

3. Oleocanthal: a natural anti-inflammatory compound

Freshly extracted extra virgin olive oil contains oleocanthal, a substance responsible for a strong “pinch” feeling in the throat, similar to the effect of ibuprofen intake, a strong anti-inflammatory drug. According to this study, oleocanthal inhibits some certain enzymes related to inflammation, showing the same action as ibuprofen, although structurally show many differences.​

https://www.ncbi.nlm.nih.gov/pubmed/16136122

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4. The role of oleocanthal in breast and prostate cancer

Oleocanthal is a compound found in extra virgin olive oil showing a strong anti-inflammatory action. Research of Enagar and his colleagues showed that oleocanthal, at a cellular level, blocks the development and the metastatic action of breast or prostate cancer cells. Even in low dosage, oleocanthal and by extend extra virgin olive oil have a powerful healing role in breast and prostate cancer.​

https://www.ncbi.nlm.nih.gov/pubmed/21328179

 

5. The anticancer activity of oleocanthal

Pei and his colleagues studied the anticancer action of oleocanthal in human liver cancer cells. The results showed that oleocanthal reduced the proliferation of cancer cells, suspended tumor growth and at the same time caused the death of many cancer cells. Also, in an experiment that was held testing the antimetastatic action of the substance, oleocanthal blocked the metastasis on the lungs. These results, give hope for the use of this compound not only on a cellular level, but on the human organism.

https://www.ncbi.nlm.nih.gov/pubmed/27259268

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6. Oleocanthal promotes only the death of cancer cells and not of          normal cells

LeGendre and his colleagues studied the effects of oleocanthal in human cancer cells. Their results showed that oleocanthal causes the death of cancer cells within 30 minutes, while normal cells don’t stand the same fate.This happens because oleocanthal acts on a certain cell mechanism that cancer cells are much more sensitive than normal cells, leading to their death while normal cells are not damaged.

​ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568762/

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7. Oleocanthal’s anticancer activity in cutaneous malignant melanoma

The aim of this study is to investigate the anticancer activity of oleocanthal against cutaneous malignant melanoma. Oleocanthal had a remarkable and selective activity for human melanoma cells versus normal dermal cells, even at low dosages.​

https://www.ncbi.nlm.nih.gov/pubmed/27266366

 

8. The effect of oleocanthal on breast cancer

The aim of this study is to investigate the effect of oleocanthal treatment on specific breast cancer cells, even at low dosages. The results have shown that oleocanthal reduces the impact of a protein, that plays an important role in the development of cancer cells and of breast cancer as well.​

https://www.ncbi.nlm.nih.gov/pubmed/26248874

 

9. Anticancer effects of oleocanthal in hepatocellular (HCC) and colorectal carcinoma (CRC)

Oleocanthal (OC) shows an anti-inflammatory and anticancer activity in liver and colon cancer cells. OC inhibits the growth of cancer without affecting normal cells, providing a strong support of the potential use of extra virgin olive oil as chemotherapeutic.

Oleocanthal (OC) shows an anti-inflammatory and anticancer activity in liver and colon cancer cells. OC inhibits the growth of cancer without affecting normal cells, providing a strong support of the potential use of extra virgin olive oil as chemotherapeutic.

https://www.ncbi.nlm.nih.gov/pubmed/28656311